ADNI Sponsors and Partners

ADNI Procedures, Protocols and Grants

ADNI Grant Applications

Grant Applications
Download the ADNI 2 Grant Application.
Download the Scientific Portion of the ADNI GO Grant Application.
Download the ADNI Grant Application.
Download the ADNI Neuropathology Core Grant Application (posted 5/16/2007)

ADNI Protocols

Download the ADNI RFA
Download the ADNI2 amendment 3 protocol.
Download the ADNI2 amendment 2 protocol.
Download the ADNI2 amendment 1 protocol.
Download the ADNI 2 Protocol.
Download the ADNI GO Protocol.
Download the ADNI 1 Protocol.
Download MRI Protocols

ADNI Study Procedures

ADNI Procedures Manuals
ADNI procedures manuals were developed as a resource for ADNI research sites. They are tailored to site Study Coordinator and support staff to provide a detailed guide to study visits with sections on MRI, PET, biofluids and safety reporting.

ADNI 1 Procedures Manual
ADNI GO Procedures Manual
ADNI 2 Procedures Manual

MRI Scans
MRI is a method that produces very clear pictures of your brain, without the use of X-rays or other invasive methods. MRI is an advanced medical technique that uses a large magnet, radio waves, antenna, and a computer to produce these images. Click here to expand/collapse this information.
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How does MR work? 
The water in your body is made up of trillions of atoms that have a magnetic moment, in other words they can act as small magnets.  When placed in a magnetic field, these atoms line up with the field, much like a compass points to the North Pole.  Radio waves of a specific frequency tip these tiny magnets away from the magnetic field.  As they tip, they gain energy.  When the radio waves are turned off, the atoms try to realign with the magnetic field, releasing the energy they gained as very weak radio signals.    
A special antenna picks up these signals from your brain and sends them to a computer, which reconstructs an image of your brain.

MRI in Alzheimer’s Disease
MRI is beneficial in ruling out other causeMRI is beneficial in ruling out other causes of dementia, such as tumors or strokes. It also may help to show the structural and functional changes in the brain that are associated with Alzheimer's disease.  One example of this would be a longitudinal study across a certain length of time which can show the amount of brain tissue that has been lost since the individual was first scanned with MRI.  By measuring one area of the brain and then again after a year, we can understand the rate of change to the brain in Alzheimer’s Disease, which can be used to show a treatment’s effectiveness (or lack of) on brain changes.
The ADNI MRI Technical Procedures manuals are developed by the ADNI Imaging Core to direct MRI technicians in the scanning of ADNI subjects and the uploading of imaging data to LONI (The Laboratory of Neuroimaging at UCLA).

ADNI 1 MRI Technical Procedures
ADNI GO MRI Technical Procedures
ADNI 2 MRI Technical Procedures
ADNI MRI Training Manual
ADNI MRI Core Protocol Selection Summary
ADNI MRI Method for Non-ADNI Studies
MRI Protocols

PET Scans
PET stands for Positron Emission Tomography. PET scanning can produce high quality pictures of different processes in your body. For brain imaging, PET can be used to take pictures of how your brain uses glucose, or sugar. Glucose is the source of energy for your brain. Scientists have learned that there are abnormal patterns of glucose use in the brains of patients with Alzheimer’s disease, and in some older people.
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% How does PET work? 
Scientists (called technologists) at the PET center make a special form of glucose that is labeled with radioactivity.  This is called fluorodeoxyglucose, or FDG.  The FDG is injected through a small needle into a vein in a person’s arm, and the PET scanner picks up this labeled.  Pictures are taken every few seconds during the time that a person is in the scanner, which shows how the brain is processing during that time period.

The PET scans being used in ADNI measure the brain's rate of glucose metabolism using the tracer [18F]Fluorodeoxyglucose.  In Alzheimer's disease, characteristic brain regions show decreased glucose metabolism, specifically regions in the temporal and parietal lobes.  We hope that following these changes over time in people with AD, people with normal aging changes, and those with mild cognitive impairment will enable us to track the disease progression as a potential biomarker for clinical trials.  PET could also become a potential biomarker used to predict who might later develop Alzheimer’s disease.
The ADNI PET technical manuals ADNI are developed by the ADNI PET Core to direct PET technologists in the scanning of ADNI subjects, and in the uploading of that file to LONI (The Laboratory of Neuroimaging at UCLA).

ADNI 1 PET Technical Procedures
ADNI GO PET Technical Procedures
ADNI 2 PET Technical Procedures
PET PIB Technical Manual

CSF Biomarker Test Instructions
Lumbar Puncture Protocol

Neuropathology Core Manual