ADNI Cognitive Testing

ADNI and UDS
ADNI Measures and the Uniform Data Set (UDS)

The tests and scales were chosen for use in this protocol because: 

  • They represent the domains of interest in this patient population
  • They adequately sample cognitive domains of interest in subjects who are normal, or have MCI or AD
  • Are able to measure change over two to three years in these patient populations
  • Subjects enrolled will not demonstrate floor or ceiling effects
  • Are reasonably efficient and can meet the practical demands of the proposed study
  • Were utilized previously in the ADCS MCI trial and worked well.

All of these instruments are widely used in multi-center trials studying normals, MCI, and early AD subjects. Additionally, they are being used by Alzheimer Disease Centers as part of their collection of a Uniform Data Set (UDS) thereby reducing the amount of testing that subjects will need to undergo who are enrolled in both ADC’s and ADNI.

The Uniform Data Set is part of the collaborative research facilitated by the National Alzheimer's Coordinating Center (NACC) among approximately 30 Alzheimer's Disease Centers funded by the National Institute on Aging.
http://www.alz.washington.edu/

Email for help with Uniform Data Set (UDS): naccmail@u.washington.edu

ADNI and UDS:  Frequently Asked Questions 

Q:  What is the order of assessment for ADNI visits, and is this different from UDS visits?

A:  The order of assessment is different from the UDS, and depends on the assessments required for that ADNI visit.  the order of assessment is the first page of each visits' Cognitive Testing Worksheets (download from: https://adni.ucsd.edu/dav/public).

Screening Visit

  • MMSE
  • Logical Memory IA (Immediate)
  • Logical Memory IIA (Delayed)

Baseline Visit

  • ADAS
  • Clock Drawing Test
  • Auditory Verbal Learning Test (A.V.L.T.)
  • Digit Span Forward
  • Digit Span Backward
  • Category Fluency Test
  • Trail Making Test
  • WAIS-R Digit Symbol Substitution Test
  • Boston Naming Test
  • Auditory Verbal Learning Test (A.V.L.T.) (30 Minute Delay)
  • American National Adult Reading Test

Month 6 and Month 18 (MCI only)

  • MMSE
  • ADAS
  • Clock Drawing Test
  • Auditory Verbal Learning Test (A.V.L.T.)
  • Digit Span Forward
  • Digit Span Backward
  • Category Fluency Test
  • Trail Making Test
  • WAIS-R Digit Symbol Substitution Test
  • Boston Naming Test
  • Auditory Verbal Learning Test (A.V.L.T.) (30 Minute Delay)

Months 12, 24, and 36 (NL and MCI only)

  • MMSE
  • ADAS
  • Clock Drawing Test
  • Logical Memory IA (Immediate)
  • Auditory Verbal Learning Test (A.V.L.T.)
  • Digit Span Forward
  • Digit Span Backward
  • Category Fluency Test
  • Trail Making Test
  • WAIS-R Digit Symbol Substitution Test
  • Boston Naming Test
  • Logical Memory IIA (Delayed)
  • Auditory Verbal Learning Test (A.V.L.T.) (30 Minute Delay)

Q: The set of forms that needs to be administered (for instance, at the screening visit) that were presented at the USD meeting in Chicago don't correspond to the set of forms that are found on the ADNI website. Which one should I use?

A: Please use only ADNI worksheets for ADNI study visits.  The cognitive testing worksheets are available on the document repository:  http://adni.ucsd.edu/dav/public. 
The ADNI Worksheets do include more cognitive assessments than the UDS and following the ADNI order of assessments is important!

Q: Is there a duplicate entry (should I entered the USD forms somewhere?)

A:  You will need to enter UDS data separately from ADNI data.   You would need to get more information on this from NACC (email: naccmail@u.washington.edu)

Q:  Regarding the order of the questionnaires that we are administering to the participants: I noticed that the FAQ and NPIQ are not supposed to be administered at the screening visit but it seems like it would make more sense to do them at the screening visit because the participant won't have to see our physician at the baseline visit and he is the one who will administer those questionnaire. I don't think that 2 to 4 weeks will change the results. Can I have those filled out at the screen visit?

A:  Please collect the FAQ and NPIQ at baseline with the rest of the in-clinic visit.  If you ever need to collect ADNI data at a time other than the ADNI visit (as in your example) please obtain approval from Dr. Petersen first (peter8@mayo.edu).

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